Abstract
In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal performance under 808-nm near-infrared (NIR) laser irradiation. mPt@PDA-RGD NPs with favorable biocompatibility exhibited remarkable SKOV-3 inhibition ability under NIR laser irradiation. Moreover, compared to mPt@PDA NPs, the RGD-functionalized NPs achieved more tumor uptake and PTT performance, which was attributed to the specific interaction between RGD of NPs and αvβ3 integrin overexpressed by SKOV-3. Importantly, cell scratch experiments indicated that the photothermal effect of mPt@PDA-RGD NPs can effectively inhibit the migration of surviving SKOV-3 cells, which was assigned to disturbance of the actin cytoskeleton of SKOV-3. Thus, mPt@PDA-RGD NPs presented great potential for targeted tumor photothermal ablation and migration inhibition.
Highlights
Tumor has emerged as a serious threat to human health
SKOV-3 cells were inoculated in culture inserts to create a clean cell gap, and mesoporous Pt (mPt)@PDA-RGD NPs at a concentration of 50 mg/ml or 100 mg/ml were added to the holes when the cells have grown to 90% to form a single layer and incubated for 6 h, cleaned with Phosphate buffered solution (PBS), and treated with 808 nm (1.5 W/cm2) for 50 s
We developed a multifunctional photothermal therapy (PTT) nanoplatform based on mPt@PDA-RGD NPs
Summary
As a popular noninvasive treatment for local tumors, photothermal therapy (PTT) has attracted great attention worldwide [1–4]. Manikandan et al [23] reported for the first time that polyvinylpyrrolidone (PVP)-coated Pt nanoparticles (NPs) have photothermal conversion capability. This inorganic nanoplatform often faces problems of low biocompatibility when used in the biomedical field. As a promising material for the preparation of multifunctional nanomaterials for cancer treatment, polydopamine (PDA) has attracted more attention in the biomedical field [24–26]. Under 808nm laser irradiation, mPt@PDA-RGD NPs exhibited excellent biocompatibility, chemotaxis of tumors, and efficient SKOV-3 inhibition ability. SCHEME 1 | The synthesis of Arg-Gly-Asp peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) and their application in targeted cancer therapy
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