Abstract
Poly(ethylene glycol)-supported l-valine-derived auxiliary 1 was prepared from poly(ethylene glycol) dimesylate in four steps. After condensation with ethyl cyclopentan-2-one carboxylate and ethyl cyclohexan-2-one carboxylate, copper-catalyzed Michael reactions of the resulting enamines 2 with methyl vinyl ketone were carried out at 23 °C for two days in acetone to give ethyl (R)-2-oxo-1-(3-oxobutyl)cyclopentane carboxylate and ethyl-(R) 2-oxo-1-(3-oxobutyl)cyclohexane carboxylate with 99% ee and 97% ee, respectively. Auxiliary 1 was recovered by simple precipitation from diethyl ether.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
