Abstract
Recent studies of captive and wild-living apes in Africa have uncovered evidence of numerous new Plasmodium species, one of which was identified as the immediate precursor of human Plasmodium falciparum. These findings raise the question whether wild apes could be a recurrent source of Plasmodium infections in humans. This question is not new, but was the subject of intense investigation by researchers in the first half of the last century. Re-examination of their work in the context of recent molecular findings provides a new framework to understand the diversity of Plasmodium species and to assess the risk of future cross-species transmissions to humans in the context of proposed malaria eradication programs.
Highlights
Recent studies of captive and wild-living apes in Africa have uncovered evidence of numerous new Plasmodium species, one of which was identified as the immediate precursor of human Plasmodium falciparum
The consensus reached from this work was that there were three Plasmodium species infecting African great apes, and that these were distinguishable based on their life-cycle and morphology
A second parasite in apes, P. rhodaini, closely resembled P. malariae found in humans, whereas the third, P. schwetzi, was more difficult to characterize and was referred to as P
Summary
Citation for published version: Rayner, JC, Liu, W, Peeters, M, Sharp, PM & Hahn, BH 2011, 'A plethora of Plasmodium species in wild apes: a source of human infection?', Trends in Parasitology, vol 27, no.
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