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Abstract
The enantioselective construction of perfluoroalkyl-containing molecules is essential in materials science, agrochemistry, and medicinal chemistry. Herein, a nickel-catalyzed reductive cross-coupling was reported to generate chiral perfluoroalkylated boronate esters from the easily prepared perfluoroalkyl-substituted α-iodoboronates. The simple and mild conditions enable a broad range of aryl iodides to deliver the products in good enantioselectivities. Additionally, compared with common acceleration by iodide salts on substrate activation, the effect of the additive was systematically investigated to disclose a pivotal role of chloride ion on nickel reduction for this transformation.
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