Abstract
A phase I study with the combination of ifosfamide + carboplatin + etoposide (ICE) was conducted in patients with advanced non-small-cell lung cancer (NSCLC). Patients who had had previous therapy were given the following dosages: ifosfamide 2 g/m2 on days 1 to 3, carboplatin 75 mg/m2 on days 1 and 2, and etoposide 80 mg/m2 on days 1 and 2. In those with no previous therapy, carboplatin 75 mg/m2 was administered on days 1 to 3. In 15 treated patients, 3 objective responses were documented, all from the 7 patients with no prior therapy. The dose limiting toxicity was leucopenia. A phase II study is required to determine the exact activity of the combination in patients with advanced NSCLC.
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