Abstract
e22138 Background: Inter-alpha Inhibitor protein family (IAIP) is a group of structurally related serine protease inhibitors produced in the liver and found at relatively high concentrations in human plasma. IAIPs have a significant role in systemic inflammation and function as an endogenous immunomodulator. Significant reduction of IAIPs level is found in decompensated septic patients due to rapid excretion through kidney. Although IAIPs correlate with several pro and anti-inflammatory cytokines in septic patients, the relationship in cancer patients is not well understood. Since many cancers may represent a systemic inflammatory state, we are interested in finding the relationship between IAIPs and malignancy, as well as exploring their potential as prognostic markers. Methods: A total of 25 blood samples (8 healthy controls and 17 cancer patients) were collected at a single time point. Plasma was used for the quantitative analysis of IAIPs (competitive ELISA using MAb 69.26), albumin, pre-albumin, CRP,...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
