Abstract
Backround: Ayurvedic medicines are alleged to be one of the sources of heavy metal toxicity. Hence, it has become necessary to prove their safety on the scientific base with appropriate evidences. Methodology: A pilot study was conducted after the preclinical safety evaluation of Rasamanikya, an arsenical formulation in Ayurveda. Ten healthy volunteers were administered Rasamanikya 125mg twice a day for fifteen consecutive days. Heavy metal estimation in blood was conducted before intervention and at the end of intervention. Student’s paired t test was applied at 5% level of significance. Result: Out of nine heavy metals, only Arsenic in blood was increased significantly in all the ten volunteers without any signs of clinical toxicity. Conclusion: The drug was found to be safe as evidenced in the previous preclinical study.
Highlights
Rasamanikya is an Arsenical formulation which is very popular and drug of choice in Ayurveda for various types of skin and blood disorders as well as infection
After that minerals were used to add in these herbal formulations to increase the potency of the herbal drugs which are known as herbo-mineral drugs
These mineral drugs were used as main drug along with other minerals known as Rasakalpa (Mineral formulations)
Summary
Rasamanikya is an Arsenical formulation which is very popular and drug of choice in Ayurveda for various types of skin and blood disorders as well as infection. It is prepared from purified Haratala (Orpiment) which is Arsenic trisulphide. Most of the heavy metals are used to prepare formulations only after purification and incineration methods of the metal according to their classical references. If they are needed for longer duration, they should be prescribed after a washout period If these methods are not followed properly according to the classical references and if they are consumed continuously without physician’s advice, the formulation may cause hazardous effect immediately or after some period depending upon the dose and route of administration of the drug. To confirm these results in human beings, this pilot study was conducted to assess the safety of Rasamanikya
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