A pilot study on predictive value of mycophenolic acid concentration monitoring in postoperative infection of renal transplant recipients

Abstract

Objective To investigate the predictive value of mycophenolic acid (MPA) concentration monitoring in postoperative infection on renal transplant recipients. Methods Forty-eight hospitalized renal transplant recipients (infection group) and 68 non-infected renal transplant recipients (control group) were enrolled in West China Hospital of Sichuan University. MPA concentration including plasma MPA concentration before dose (MPA-C0), plasma MPA concentration 0.5 h after dose (MPA-C0.5), plasma MPA concentration 2 h after dose (MPA-C2), plasma MPA concentration 4 h after dose (MPA-C4), the simplified MPA AUC (MPA-AUC0-4) and the pre-dose blood concentration of Tacrolimus (TAC-C0), relevant laboratory data, imaging and other auxiliary examination data were analyzed. Results In the infected group, the TAC-C0 of the renal transplant recipients was basically stable before and after admission, all near the stability level (P>0.05). Before admission, MPA-AUC0-4 and MPA-C4 of renal transplant recipients in the infected group were significantly higher than those in the control group (P 0.05), MPA-C2, MPA-C4 and MPA-AUC0-4 were slightly lower than those in the infected group (P>0.05), except for MPA-C0. There was no significant difference in concentration and MPA-AUC0-4 between the control group and the control group (P>0.05). Conclusion MPA-AUC0-4 and MPA-C4 have early predictive significance for the occurrence of infection in renal transplant recipients. The monitoring of mycophenolic acid concentration is helpful for the prevention and control of infection in renal transplant recipients. Conclusion MPA-C4 and MPA-AUC0-4 possess an early predictive value for infection of renal transplant recipients.. Monitoring MPA concentration is helpful for prevention and control of infection in renal transplant recipients. Key words: Mycophenolic acid; Therapeutic monitoring; Infection; Renal transplantation