Abstract
Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of Lactobacillus casei LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (p < 0.0001), while malondialdehyde (MDA) levels decreased (p < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (p < 0.05, respectively). Escherichia coli, Enterococcus, and Bacteroides expression was significantly reduced (p < 0.05), while Clostridium leptum, Bifidobacterium, and Lactobacillus expression increased (p < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest L. casei LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.
Highlights
Recent research has illustrated that long-lived individuals have high intestinal microbial diversity and are rich in several potentially beneficial probiotic cultures, indicating a link between healthy aging and gut microbiota [2]
We evaluated effects of the LTL1879 strain on the health of young individuals by examining blood biochemistry, oxidation, and inflammation markers; as well as monitoring gut microbiota changes in young volunteers before, during, and after continuous probiotic supplementation
After 3 weeks of probiotic intervention, serum IL-10 levels in the probiotic group significantly increased by 8.10% (p < 0.05), while no changes were observed for the placebo group (Figure 3A)
Summary
It is believed that intestinal flora plays an important role in human health [1], and evidence shows its close relationship to human health and longevity. Recent research has illustrated that long-lived individuals have high intestinal microbial diversity and are rich in several potentially beneficial probiotic cultures, indicating a link between healthy aging and gut microbiota [2]. It has been reported that the composition of the gut microbiota of healthy, long-lived individuals is significantly different from that of young individuals and the frail elderly [3,4,5,6]. Probiotic strains derived from long-lived individuals exhibited excellent antioxidant [7,8], anti-inflammatory, cholesterol-lowering [9], immune regulating [10], and anti-tumor activities [11]
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