Abstract

AlloSCT may be beneficial to patients with relapsed/refractory HD and NHL by providing a graft versus lymphoma effect. Carella et al (JCO 2000) and Gutman et al (BMT 2005) demonstrated the feasibility and success of MA AutoSCT followed by RI AlloSCT in adults with refractory lymphoma. We investigated MA AutoSCT followed by RI AlloSCT in children with relapsed/refractory HD/NHL. Twelve patients entered post reinduction therapy (3CR+2PR post Ifos/Carbo/VP-16, 1PR+1CR post Ifos/Vinorelbine, 1PR post Topotecan/Ifos/Carbo, 1CR post vinorelbine/gemcitabine, 1PR post cytarabine/VP-16/MTX, 1PR post cytarabine/VP-16/L-asp/prednisone, 1CR post carmustine/VP-16/cyclophosphamide).

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