Abstract
Forty-six patients with previously untreated, advanced ovarian cancer received carboplatin (JM8, CBDCA) and chlorambucil (CLB) to assess the efficacy and toxicity of this combination. Carboplatin 300 mg m-2 was given on day 1 with CLB 10 mg daily for 7, 10 or 14 days; 6 treatment courses were given at 4-6 weekly intervals in the absence of disease progression. Tumour response was assessed, where possible, by restaging laparotomy after 6 treatment cycles. Five complete and 16 partial remission were seen in 37 evaluable patients giving an overall response rate of 57%. The median survival of all patients was 15 months. The major toxicity was myelosuppression. Nausea and vomiting were generally minor (WHO, grades I or II) and most courses were given on an outpatient basis. Leucopenia was the major factor causing treatment delays, particularly with the 10 and 14 day CLB regimens. Thrombocytopenia was minimal in the early chemotherapy cycles but the data suggest that cumulative toxicity may occur. This combination may provide a satisfactory degree of efficacy with less toxicity than cisplatin-based regimens.
Highlights
MethodsEntry into the study was precluded by prior therapy or renal impairment (creatinine clearance
Thrombocytopenia was minimal in the early chemotherapy cycles but the data suggest that cumulative toxicity may occur
This combination may provide a satisfactory degree of efficacy with less toxicity than cisplatin-based regimens
Summary
Entry into the study was precluded by prior therapy or renal impairment (creatinine clearance 4.0 x 109 1 -1, and platelets > 100 x 109 1 -1. In the later phase of the trial, the threshold WBC for retreatment was reduced to 3.0 x 1091 -1
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