Abstract
<b><i>Introduction:</i></b> Aberrant fibrosis in central centrifugal cicatricial alopecia (CCCA) is thought to be driven by persistent low-grade inflammation, but the source of inflammation is unclear. Alterations in the scalp microbiota may contribute to inflammation and thus provide a target for therapeutic intervention. We sought to compare the bacterial and fungal cutaneous scalp microbiota in patients with CCCA versus controls. <b><i>Methods:</i></b> Six patients with CCCA and seven controls were sampled at the vertex scalp. 16S rRNA sequencing of V3-V4 region and internal transcribed spacer amplicon sequencing was used to compare bacterial and fungal microbiomes. <b><i>Results:</i></b> A significantly higher relative abundance of <i>Corynebacterium</i> was noted in patients with CCCA versus controls. No significant difference in scalp fungal or bacterial microbiota composition was observed. <b><i>Limitations:</i></b> V3-V4 sequencing can be limited in detection of major skin bacterial species. <b><i>Conclusion:</i></b> CCCA is characterized by a distinct bacterial microbiome community and high relative abundances of <i>Corynebacterium</i>. Future studies should characterize the relationship between <i>Corynebacterium</i> and scalp inflammation and the role it may play in the progression of CCCA.
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