Abstract

BackgroundFew trials have evaluated the effectiveness of psychological treatment in improving depression by the end of pregnancy. This is the first pilot randomised controlled trial (RCT) of individual cognitive behavioural therapy (CBT) looking at treating depression by the end of pregnancy. Our aim was to assess the feasibility of delivering a CBT intervention modified for antenatal depression during pregnancy.MethodsWomen in North Bristol, UK between 8–18 weeks pregnant were recruited through routine contact with midwives and randomised to receive up to 12 sessions of individual CBT in addition to usual care or to continue with usual care only. Women were eligible for randomisation if they screened positive on a 3-question depression screen used routinely by midwives and met ICD-10 criteria for depression assessed using the clinical interview schedule – revised version (CIS-R). Two CBT therapists delivered the intervention. Follow-up was at 15 and 33 weeks post-randomisation when assessments of mental health were made using measures which included the CIS-R.ResultsOf the 50 women assessed for the trial, 36 met ICD-10 depression criteria and were randomised: 18 to the intervention and 18 to usual care. Thirteen of the 18 (72%) women who were allocated to receive the intervention completed 9 or more sessions of CBT before the end of pregnancy. Follow-up rates at 15 and 33 weeks post-randomisation were higher in the group who received the intervention (89% vs. 72% at 15 weeks and 89% vs. 61% at 33 weeks post-randomisation). At 15 weeks post-randomisation (the end of pregnancy), there were more women in the intervention group (11/16; 68.7%) who recovered (i.e. no longer met ICD-10 criteria for depression), than those receiving only usual care (5/13; 38.5%).ConclusionsThis pilot trial shows the feasibility of conducting a large RCT to assess the effectiveness of CBT for treating antenatal depression before the end of pregnancy. The intervention could be delivered during the antenatal period and there was some evidence to suggest that it could be effective.Trial registrationISRCTN44902048

Highlights

  • Few trials have evaluated the effectiveness of psychological treatment in improving depression by the end of pregnancy

  • Some of the consequences attributed to postnatal depression could be due to antenatal depression

  • Recruitment According to computerised records from NHS Bristol, during the recruitment period of the study between May 2010 and February 2011, there were approximately 5,409 women who attended booking clinics, of those 154 women screened positive on the 3-question screen for depression and were potentially eligible for assessment for the trial

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Summary

Introduction

Few trials have evaluated the effectiveness of psychological treatment in improving depression by the end of pregnancy. There has been considerably more research on postnatal depression and its consequences than on antenatal developing foetus may include low birth weight, preterm delivery, and reduced motor activity [13,14,15,16,17]. Many of those depressed in pregnancy do not recover and depression continues postnatally. Identification and treatment of depression at this time has become a health service priority and has been recommended in National treatment guidelines in the UK (NICE ) [18]

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