Abstract
Hypertrophic stimuli, such as mechanical loading and heat stress, could up‐regulate heat shock proteins (HSPs) in muscle cells. Although it has been proposed that HSPs has several cellular functions, the physiological roles for HSPs induction in skeletal muscles is still unclear. The induction of HSPs expression is regulated by heat shock factor 1 (HSF1), which binds to heat shock elements located on the upstream region of all Hsp genes. In the present study, using the HSF1 knockout (HSF1‐KO) mice, we examined the role of HSPs inthe reloading‐associated regrowth of atrophied soleus muscle. The regrowth was induced by the reloading on soleus following 2‐week‐hindlimb suspension. Increment in the protein content and the up‐regulations of HSPs of soleus muscles in HSF1‐KO mice was smaller than that of wild type animals. Results from this study indicated that the up‐regulation of HSPs may facilitate the protein synthesis in skeletal muscle cells. This study was supported, in part, by Grant‐in‐Aid for Scientific Research (B, 20300218, KG; A, 18200042, TY; S, 19100009, YO) from Japan Society for the Promotion of Science, and Research Grant from KAO Health Science Research (KG).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
