Abstract

Circadian rhythms allow organisms to regulate daily processes, such as sleep, feeding and body temperature. A subset of the compounds that regulate circadian rhythms in humans has been simulated in a quantitative temporal physiological model using the Center for Research and Education in Aging Language (CREAL). CREAL is a language that can be used to describe biological systems from a macro to a molecular scale, and simulations can take place over time scales such as an hour or a day or a longer period of time. The simulation of the circadian rhythms shows the concentration of compounds throughout the model, during a 24 hour period. The release of melatonin, which modulates the sleep cycle is simulated with respect to events that take place in the suprachiasmatic nucleus (SCN). The model also shows changes in cortisol levels as well as many other compounds that are involved in regulating daily processes.

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