A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt.

Elsayed M Abouelleef,Mowafak M Mahrouka,Sherine E Salem,Guillermo Mendoza-Diaz

doi:10.1155/2021/4018843

Abstract

The nano-CuCl2.2H2O salt was prepared by the ball milling method. The association parameters for bulk and nano-CuCl2 salts in H2O are estimated at different temperatures using the conductivity method by applying the Fuoss–Shedlovsky equation and it was higher for nano-CuCl2 than bulk CuCl2 salt. The interaction between the cation (Cu2+) and ligand (ceftriaxone) in H2O was determined also by the conductometric method. Two stoichiometric complexes 1/2 and 1/1 (M/L) are estimated and follow the order Kf (1/1) > Kf (1 : 2) and ∆Gf (1/1) > ∆Gf (1/2) for (M : L) (in negative values) indicate the favorable of formation of (1/1) complex compared to the (1 : 2) complex. The Gibbs free energies change was increased in negative signs with increasing the temperature. The antimicrobial activities of CFT, bulk Cu-CFT complex, and nano-Cu-CFT complex were studied on LB agar by the disc diffusion technique against clinical isolates of gram-negative bacteria (Klebsiella pneumonia and Pseudomonas aeruginosa) and Fungi (Candida albicans). It was observed that (CFT) has a higher zone of inhibition and antibacterial activity than that of bulk and nano-Cu-CFT complexes in Klebsiella pneumonia and Pseudomonas aeruginosa (gram-negative bacteria). The nano-Cu-CFT complex showed a higher clear zone of inhibition and antifungal activity against candida than bulk Cu-CFT complex while the absence of the inhibition zone in CFT, so nano-Cu-CFT complex, can be used as an antifungal drug.

Highlights

Nanoparticles (NPs) are a wide class of materials that have a state between bulk and atomic or molecular structures in different shapes of 0D, 1D, 2D, or 3D and have a great scientific interest [1,2,3,4,5]
Nanoparticles (NPs) such as gold, silver, platinum, and palladium showed colors with the variation of shape and size and characteristic properties that can be utilized in bioimaging applications [20]. Another application of nanoparticles is the synthesis of photocatalysis S-doped TiO2 nanoparticles and the study of their photocatalytic, antimicrobial, and antioxidant activities under sunlight illumination [21]
Biological Activity. e antimicrobial activities of CFT, bulk Cu-CFT complex, and nano-Cu-CFT complex were studied on LB agar by the disc diffusion technique against clinical isolates of gram-negative bacteria (Klebsiella pneumonia and Pseudomonas aeruginosa) and fungi (Candida albicans)

Summary

Introduction

Nanoparticles (NPs) are a wide class of materials that have a state between bulk and atomic or molecular structures in different shapes of 0D, 1D, 2D, or 3D and have a great scientific interest [1,2,3,4,5]. Nanoparticles (NPs) such as gold, silver, platinum, and palladium showed colors with the variation of shape and size and characteristic properties that can be utilized in bioimaging applications [20]. Another application of nanoparticles is the synthesis of photocatalysis S-doped TiO2 nanoparticles and the study of their photocatalytic, antimicrobial, and antioxidant activities under sunlight illumination [21]

Methods

Results

Conclusion