Abstract
RNA tumor viruses have been shown to contain two to three RNA subunits consisting of identical nucleotide sequences (Beemon et al. , 1974; Billeter et al. , 1974). It remained unclear whether these sequences were uniquely arranged or circularly permuted. The organization of the genome of Rous sarcoma virus (Prague strain, subgroup B) has now been investigated by locating 29 large oligonucleotides, arising by digestion of 36S viral RNA with RNAase T 1 , relative to the poly(A) segment of the RNA. A unique arrangement of the oligonucleotides was found, demonstrating that all 36S subunits are similar in their sequences. A physical map of the genome has been constructed and three oligonucleotides absent in a transformation-defective variant of the virus were located in a region near the 3′ end of the RNA.
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