Abstract
A photolabile derivative ( 1) of the anticancer drug, 5-fluorodeoxyuridine ( 2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation ( λ = 350 nm) resulted in potent inhibition of cell growth.
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