A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine

Abstract

Inflammation widely occurs in various tissues and organs in the human body. Rapid and accurate diagnosis of inflammation is essential to avoid severe complications. This study aims to obtain a non-destructive, fast, and comprehensive tool for the detection of pathogenic sites of inflammation in vivo. A fluorescence and photoacoustic dual-mode imaging probe, Cy-ASP, was first developed to detect inflammatory biomarker LTA4H with good sensitivity and selectivity in living small animal. Furthermore, the relationship between LTA4H and NF-κB in an LPS-induced cell was investigated. This work provides a new idea for the clinical diagnosis of pneumonia and hepatitis and revealing the upstream regulatory mechanism of LTA4H in the pneumonia model.