Abstract
The effect of the phorbol ester phorbol12,13-dibutyrate (PDB), an activator of protein kinase C, on endothelium-dependent relaxation was studied in noradrenaline-constricted isolated aortic ring preparations of the rabbit. Endothelium-dependent relaxation induced by acetylcholine or substance P was inhibited by PDB (⩾10 −7 M). Endothelium-dependent relaxation induced by the calcium ionophore A23187 (7.5 × 10 −8 and 10 −7 M) was unaffected by PDB (to 10 −6 M). The mechanical responses to acetylcholine or sodium nitroprusside in endothelium-denuded rings were not altered by PDB (to 10 −6 M). The results suggest a role for protein kinase C in receptor-mediated EDRF release mechanisms.
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