Abstract
In a clinical study of type IIA, the quantified 80% ethanol extract from the stem bark of Nauclea pobeguinii (Pobég.) E.M.A. Petit containing 5.6% strictosamide appeared to be effective in the treatment of uncomplicated falciparum malaria when taken for seven days, at a dose regimen of two 500mg capsules three times daily for 3 days, followed by one 500mg capsule three times daily for four days. No serious side effects were noted. The Phase IIA clinical trial was carried out according to the WHO 14 days test (WHO 2003) and the results revealed that all eleven patients were completely cleared of parasitaemia and fever on days 3, 7 and 14, except for one patient.
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