A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.

Abstract

Human Gene TherapyVol. 11, No. 3 A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination with Escalating Doses of Ganciclovir in Patients with Cutaneous Metastatic Malignant MelanomaPublished Online:6 Jul 2004https://doi.org/10.1089/10430340050015950AboutSectionsPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited byMolecular Imaging of Gene TherapyMicrovesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy2 December 2019 | Molecular Cancer Therapeutics, Vol. 18, No. 12Bioluminescence Imaging of Cancer TherapyDual-therapeutic reporter genes fusion for enhanced cancer gene therapy and imaging23 August 2012 | Gene Therapy, Vol. 20, No. 5Therapeutic live vaccines as a potential anticancer strategy20 June 2012 | International Journal of Cancer, Vol. 131, No. 8Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals14 July 2011 | Gene Therapy, Vol. 19, No. 3Suicide Gene TherapyGene Therapy for Malignant Pleural MesotheliomaHematology/Oncology Clinics of North America, Vol. 19, No. 6Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma4 March 2005 | Cancer Gene Therapy, Vol. 12, No. 7Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs22 September 2003 | Cancer Gene Therapy, Vol. 10, No. 10Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing29 April 2003 | Cancer Gene Therapy, Vol. 10, No. 5Oncolytic adenoviruses for treatment of brain tumours23 February 2005 | Expert Opinion on Biological Therapy, Vol. 2, No. 8Adenovirus vector–mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane18 October 2002 | Cancer Gene Therapy, Vol. 9, No. 11Gene Therapy for Malignant Mesothelioma25 June 2013Effective Gene Transfer to Human Melanomas via Integrin-Targeted Adenoviral Vectors Takafumi Nakamura, Kenzo Sato, and Hirofumi Hamada6 July 2004 | Human Gene Therapy, Vol. 13, No. 5Emerging new therapies for chemotherapy—resistant cancer using adenoviral vectorsDrug Resistance Updates, Vol. 5, No. 1The Release of Inflammatory Cytokines from Human Peripheral Blood Mononuclear Cells In Vitro Following Exposure to Adenovirus Variants and Capsid James N. Higginbotham, Prem Seth, R. Michael Blaese, and W. Jay Ramsey6 July 2004 | Human Gene Therapy, Vol. 13, No. 1Treatment of Mesothelioma Using Adenoviral-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Gene in Combination with GanciclovirRecombinat adenovirus vectors for gene therapy and clinical trials (A review)Acta Microbiologica et Immunologica Hungarica, Vol. 48, No. 3-4Toxicity Assessment of Intratumoral Injection of the Herpes Simplex Type I Thymidine Kinase Gene Delivered by Retrovirus in Patients with Refractory CancerMolecular Therapy, Vol. 4, No. 2Gene Therapy of Metastatic DiseaseSurgical Oncology Clinics of North America, Vol. 10, No. 2Advances in skin gene therapy24 February 2005 | Expert Opinion on Investigational Drugs, Vol. 9, No. 9The Journal of Gene Medicine, Vol. 2, No. 5 Volume 11Issue 3Feb 2000 To cite this article:A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination with Escalating Doses of Ganciclovir in Patients with Cutaneous Metastatic Malignant Melanoma.Human Gene Therapy.Feb 2000.487-503.http://doi.org/10.1089/10430340050015950Published in Volume: 11 Issue 3: July 6, 2004PDF download