A phase 1b study of combined angiogenesis blockade with nesvacumab, a selective monoclonal antibody (MAb) to angiopoietin-2 (Ang2) and ziv-aflibercept in patients with advanced solid malignancies.

Abstract

2522 Background: Nesvacumab (N) is a selective, human Ang-2 MAb, that potently blocks Ang2 signaling through the Tie2 receptor. Ziv-aflibercept (Z) is a recombinant human fusion protein and a decoy...