Abstract
7009 Background: Ibrutinib (Ib), an oral covalent BTK inhibitor, has significant activity in relapsed/refractory (R/R) CLL. Adding ofatumumab (O), an anti-CD20 antibody, to chemotherapy in CLL can improve response and progression free survival (PFS). Here, Ib was given with O in 3 different administration sequences. Methods: Patients (pts) with R/R CLL/SLL, PLL or Richter’s transformation (RT) after ≥2 prior therapies including a purine analog were treated with 420 mg Ib daily and 300/2000 mg O (8 x weekly/then 4 x monthly) in 28-day cycles until progressive disease (PD). Group (G) 1 had 1 cycle of Ib monotherapy, then O was added. G2 started O on Day (D) 1/Cycle (C) 1 and Ib on D2/C1. G3 had 2 cycles of O monotherapy, then Ib was added on D1/C3. Results: 71 pts (27, 20, 24 in G1, 2, 3) were enrolled. Median age was 64 y; 61% had Rai stage III/IV; 65 pts had CLL, 1 SLL, 2 PLL and 3 RT; 75% had lymph nodes ≥5 cm; 44% had del(17p); 31% had del(11q). The most frequent AEs were diarrhea (68%), infusion-relate...
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