Abstract
Stereotactic radiosurgery (SRS) has been an alternative for those with limited brain metastases to avoid the potential cognitive side effects of whole brain radiation (WBRT). Despite excellent local control with SRS, patients remain at risk for intracranial recurrence. Preclinical studies suggest that combining angiogenic blockade with radiation may result in increased DNA damage. Sorafenib is an oral multi-kinase inhibitor which has inhibitory effects on both tumor proliferation and tumor angiogenesis.
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