Abstract
SummaryA study was carried out to investigate the pharmacokinetic parameters of erythromycin lactobionate and erythromycin ethylsuccinate in patients with acute exacerbation of chronic bronchitis. Erythromycin concentrations in serum and sputum were determined after 1 g oral doses of the ethylsuccinate and after a 500 mg intravenous injection of the lactobionate. Models of the doses and regimens were simulated from the data. The results demonstrated the fast diffusion of erythromycin lactobionate in the peripheral compartment. Plasma and bronchial secretion concentrations of the two products were particularly high, especially in the case of the lactobionate which, therefore, is indicated in the most severe infections.
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