A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties

Jorge Andrés Montaña,Yolima Baena,León Darío Perez

doi:10.1590/s2175-97902018000217183

Jorge Andrés Montaña, Yolima Baena + Show 1 more

Open Access

https://doi.org/10.1590/s2175-97902018000217183

Copy DOI

Abstract

Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.

Highlights

Interpolyelectrolyte complexes (IPECs) are selfassembled materials formed in aqueous medium by two oppositely charged polyelectrolytes
The structure and properties of IPEC depends on the characteristics of the polymers and presence of other functional groups and are affected by preparation parameters and physicochemical properties of the solution (Fukuda, Kikuchi, 1979; Petrov, Antipov, Sukhorukov, 2003; Pergushov, Buchhammer, Lunkwitz, 1999; Kayitmazer, 2016)
stoichiometric interpolyelectrolyte complex (SIPEC) can modify the solubility behavior of dexibuprofen

Summary

Introduction

Interpolyelectrolyte complexes (IPECs) are selfassembled materials formed in aqueous medium by two oppositely charged polyelectrolytes. IPECs exhibit interesting properties for use in pharmaceutical applications as polymeric drug carriers with controlled release, micro- and nanoencapsulation of biologically active substances, preparation of biodegradable and biocompatible membranes, and the design of systems for the delivery of proteins and genes (Devi, Maji, 2009; Bawa et al, 2011; Arora et al, 2011; Ramasamy et al, 2014; Čalija et al, 2013; Pergushov et al, 2013) These macromolecular complexes are mainly stabilized by electrostatic interactions between oppositely charged ionic groups on polymers, interactions such as hydrogen bonding, Van der Waals, and hydrophobic forces contribute to their formation (Lankalapalli, Kolapalli, 2009). Given that IPECs do not always correspond to equilibrium structures because of the polymeric nature of the components, their properties are be affected by other experimental variables, such as stirring speed and blending order (Kabanov, 1994)

Objectives

Methods

Results

Conclusion