A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1

Richard A Kahn,David G Lambright

doi:10.1016/j.str.2015.10.002

A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1

Richard A Kahn, David G Lambright

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https://doi.org/10.1016/j.str.2015.10.002

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Journal: Structure	Publication Date: Nov 1, 2015
Citations: 4	License type: publisher-specific-oa

Affiliation: Emory University, University of Massachusetts Chan Medical School

#PH Domain #Phospholipid Binding Sites + Show 8 more

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Abstract

In this issue of Structure, Jian et al. (2015) report the crystal structures of the apo- and dibutyryl-PI(4,5)P2 bound forms of the PH domain from the ARF GAP, ASAP1. This PH domain has two anionic phospholipid binding sites proposed to work in concert to regulate ASAP1 GAP activity.

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