Abstract
BackgroundThis study aims to compare the difference of the brain changes of glucose metabolism between temporal lobe epilepsy patients (TLE) with major depressive disorder and temporal TLE without major depressive disorder.MethodsA total of 24 TLE patients, who met the inclusion criteria of our hospital, were enrolled in this study. They were divided into a TLE with depression group (n = 11) and a TLE without depression group (n = 13), according to the results of the HAMD-24 Scale. Two groups patients were examined using 18F-FDG PET brain imaging.ResultsThe low metabolic regions of the TLE with depression group were mainly found in the left frontal lobe, temporal lobe and fusiform gyrus, while the high metabolic regions of the TLE with depression group were mainly located in the right frontal lobe, visual joint cortex and superior posterior cingulate cortex. Both of the TLE groups had high metabolic compensation in the non-epileptic area during the interictal period.ConclusionsThere is an uptake difference of 18F-FDG between TLE patients with depression and TLE patients without depression in multiple encephalic regions.
Highlights
This study aims to compare the difference of the brain changes of glucose metabolism between tem‐ poral lobe epilepsy patients (TLE) with major depressive disorder and temporal TLE without major depressive disorder
The inclusion criteria were as follows: (1) patients who met the diagnostic criteria of the International League Against Epilepsy (ILAE) for TLE; (2) the symptoms of seizure accorded with TLE clinical features, and the video electroencephalogram (VEEG) indicated that the abnormal discharge was confined to the temporal lobe at the interictal stage, and the epileptic discharge at the interictal stage originated from the temporal lobe; (3) patient age ≥ 18 years old; (4) Mini-mental State Examination (MMSE) scores ≥ 24 points; (5) a PET examination showed that the depression was during the interictal period of epileptic seizures, and the HAMD-24 scored ≥ 8 points
The laterality of the attack and the degree of hypometabolism of the temporal lobe during an attack may be the interdependent factor leading to the risk of. This present study found that the hypometabolic regions of the TLE with depression group are mainly located in the right frontal lobe, temporal lobe and fusiform gyrus compared with the TLE without depression group, while the hypermetabolic regions of the TLE
Summary
This study aims to compare the difference of the brain changes of glucose metabolism between tem‐ poral lobe epilepsy patients (TLE) with major depressive disorder and temporal TLE without major depressive disorder. Comorbid depressive disorder in epileptic patients is often ignored, Previous studies have shown that the difference in important structures of the limbic system in TLE patients with depression is significant when compared to non-depressive patients [4,5,6]. Bromfield et al [7] did a comparative study of the glucose metabolism of the brain in patients with depression, using 18F-2-fluorodeoxyglucose positron emission tomography (FDG-PET), twenty years ago. They found a decrease in glucose metabolism in the frontal region.
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