Abstract
Predicting complications of diseases such as rheumatoid arthritis (RA) as well as the efficacy and toxicity of drugs used to treat the disease based on an understanding of genetic differences is leading to the development of highly individualized, personal medicine. The prevention of cardiovascular complications of RA has assumed greater importance as our ability to treat the underlying joint disease has improved and it may be possible to predict which patients with RA are at greatest risk of developing cardiovascular disease.
Highlights
Predicting complications of diseases such as rheumatoid arthritis (RA) as well as the efficacy and toxicity of drugs used to treat the disease based on an understanding of genetic differences is leading to the development of highly individualized, personal medicine
Elevated homocysteine levels have long been associated with atherosclerotic cardiovascular disease (ASCVD) and homocysteine is a direct toxin for the vascular endothelium
The A1298C polymorphism is quite common and is present in as many normal individuals (40% were AC heterozygotes and 10% were homozygous CC) as RA patients (41% were heterozygotes and 10% were homozygous for the C allele)
Summary
Predicting complications of diseases such as rheumatoid arthritis (RA) as well as the efficacy and toxicity of drugs used to treat the disease based on an understanding of genetic differences is leading to the development of highly individualized, personal medicine. RA primarily affects the joints, it is a systemic disease that clearly contributes to a marked increase in the risk for development of ASCVD (for example, [2]). By inhibiting MTHFR, diminishes recycling of homocysteine to methionine, leading to
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