A penalized likelihood approach for efficiently estimating a partially linear additive transformation model with current status data

Abstract

Current status data are commonly encountered in medical and epidemiological studies in which the failure time for study units is the outcome variable of interest. Data of this form are characterized by the fact that the failure time is not directly observed but rather is known relative to an observation time, i.e., the failure times are either left- or right-censored. Due to its structure, the analysis of such data can be challenging. To circumvent these challenges and to provide for a flexible modeling construct which can be used to analyze current status data, herein a partially linear additive transformation model is proposed. In the formulation of this model, constrained B-splines are employed to model the monotone transformation function and nonparametric covariate effects. To provide for more efficient estimators, a penalization technique is used to regularize the estimation of all unknown functions. An easy to implement hybrid algorithm is developed for model fitting, and a simple and consistent estimator of the large-sample variance-covariance matrix for regression parameter estimators is proposed. It is shown theoretically that the proposed estimators of the finite-dimensional regression coefficients are root-n consistent, asymptotically normal, and achieve the semiparametric information bound, while the estimators of the nonparametric components attain the optimal rate of convergence. The finite-sample performance of the proposed methodology is evaluated through extensive numerical studies and is further demonstrated through the analysis of human papillomavirus (HPV) data.