Abstract
Microbial genomics as a strategy for developing antimicrobial drugs “failed to deliver” in part because “we don't understand the biology,” says Eric Brown of McMaster University in Hamilton, Ontario, Canada. His strategy to overcome that impasse involves using antibiotics to “probe biology” and thus learn more about “essential functions” of microbes en route, perhaps, to novel or improved antimicrobials. He spoke during the symposium, “A New World of Academic Antimicrobial Discovery,” part of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), held in Chicago, Ill., last September.
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