A Pediatric Suicide Attempt by Ingestion of Metformin, Glimepiride and Sulpiride: A Case Report and Literature Review

Gharsalli Tarek,Garrab Kais

doi:10.4172/2161-0495.1000310

Abstract

A case of a pediatric patient poisoning after ingestion of metformin, glimepiride and sulpiride, he was presented to the emergency service with symptoms and signs of hypoglycemia. Using a risk assessment based approach, the management of glimepiride and metformin overdose is discussed. Glimepiride overdose invariably results in profound hypoglycemia that requires resuscitation with IV dextrose and the use of octreotide as an antidote. Metformin overdose rarely causes problems. The acute sulpiride poisoning is poorly reported in the medical literature.

Highlights

Children suffering from physical, mental or psychological problems are being increasingly evaluated and treated in pediatric clinical [1]
On 11 December 2015, his mother thought that he had been sleeping. She wanted to wake him up, but it was in vain. She took him to the emergency service of the regional hospital of Kasserine, biochemistry panel revealed normal renal functioning but severe hypoglycemia (0.3 g/L), no lactic acidosis, a rhabdomyolysis (arterial blood gas pH, 7.42; pCO(2) 32.4 mmHg,; pO(2), 82 mm Hg; HCO(3), 22.9 mmol/L; creatinine 55 μmol/L, CPK 852 UI/L, He was perfused by glucose solution and transferred to the intensive care unit at the same hospital
Metformin belongs to a class of biguanide

Summary

Introduction

Children suffering from physical, mental or psychological problems are being increasingly evaluated and treated in pediatric clinical [1]. She took him to the emergency service of the regional hospital of Kasserine, biochemistry panel revealed normal renal functioning but severe hypoglycemia (0.3 g/L), no lactic acidosis, a rhabdomyolysis (arterial blood gas pH, 7.42; pCO(2) 32.4 mmHg,; pO(2), 82 mm Hg; HCO(3), 22.9 mmol/L; creatinine 55 μmol/L, CPK 852 UI/L, He was perfused by glucose solution and transferred to the intensive care unit at the same hospital The day, his mother came back home in order to search his room, she found that he ingested the treatments of his father, which are metformin, glimepiride and sulpiride. He quitted the intensive care unit and moved to the pediatric service where he stayed one day before coming back home

Discussion

Findings

Disclosure of Interest