Abstract
Abstract Objectives Platelet aggregation in the presence of ethylenediaminetetraacetic acid (EDTA), is called EDTA-related pseudothrombocytopenia (EDTA-PTP), resulting in low platelet count by automatic cell counters. Case presentation Herein, we present a case of a 5-year-old female, who was referred to our laboratory due to persistent thrombocytopenia. Conclusion Our case report discusses the efficiency of the histograms and flag warnings of the cell counter, indicating the importance of these variables.
Highlights
Platelet aggregation in the presence of ethylenediaminetetraacetic acid (EDTA), a widely used anticoagulant for complete blood count (CBC) analysis is called EDTA-related pseudothrombocytopenia (EDTA-PTP)
EDTA-PTP is not a rare phenomenon with its 15–17% incidence in patients evaluated for thrombocytopenia, the diagnosis may still delay unless a peripheral blood smear examination was performed [2, 3]
We describe a pediatric case of EDTA-PTP
Summary
Platelet aggregation in the presence of ethylenediaminetetraacetic acid (EDTA), a widely used anticoagulant for complete blood count (CBC) analysis is called EDTA-related pseudothrombocytopenia (EDTA-PTP). EDTA-PTP results in low platelet count by automatic cell counters, especially when the sample was analyzed a while after the phlebotomy procedure. Hematology analyzers might count the platelet clumps as lymphocytes, and increased white blood cell (WBC) count might occur occasionally [1]. EDTA-PTP is not a rare phenomenon with its 15–17% incidence in patients evaluated for thrombocytopenia, the diagnosis may still delay unless a peripheral blood smear examination was performed [2, 3]. EDTA-PTP should be considered when a low platelet count. Hocaoglu-Emre and Yavuz Aksu: Implementation of the histograms by the automated cell counters without any other clinical symptoms of thrombocytopenia is present. We describe a pediatric case of EDTA-PTP
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