A Patient with Graves' Disease and Three Types of Thyroid Carcinoma

Abstract

The prevalence of epithelial cell thyroid cancer (TC) has been increasing in patients with Graves’ disease (GD) (1). In addition, anaplastic TC (ATC) may arise in the setting of papillary TC (PTC). It is likely, however, that the patient we report here, who had GD and three types of TC, is very unusual. A 71-year-old woman presented at another facility with tremor, hyperhidrosis, palpitations, weakness, reduced appetite, and recent 20-kg weight loss. She had a 10-year history of hypertension. Hyperthyroidism was diagnosed, and methimazole, 40 mg daily, was prescribed. Three years later symptoms of hyperthyroidism were present but milder. She was examined in our clinic and was noted to have one hard 2-cm nodule in the right thyroid lobe (RL) and one hard 3-cm nodule in the left thyroid lobe (LL). Prior ultrasonography (US) showed a solid, heterogeneous 2.02-cm mass in the RL and a solid 16.43-cm heterogeneous mass with microcalcifications in the LL. She was clinically euthyroid on 30 mg methimazole daily. Serum thyrotropin (TSH) was 0.029 mIU=mL (0.27–4.2), free thyroxine was 1.52 ng=dL (0.93–1.7), and TSH receptor antibodies were positive at 162 U=L (RV 11.0 U=L). Technetium-pertechnetate scintigraph showed an enlarged thyroid with cold areas in both lobes. US fine-needle aspiration biopsy of both nodules revealed a follicular neoplasm in the RL and a Hurthle cell tumor in the LL. The patient underwent left loboisthmectomy; frozen-section analysis revealed Hurthle cell carcinoma, and a total thyroidectomy was performed shortly thereafter. Histopathological examination showed a 23.4-cm Hurthle cell tumor in the LL. There was also a 1.3-cm follicular carcinoma in the RL and adjacent to it a 0.4-cm anaplastic carcinoma (Fig. 1). The anaplastic carcinoma contained anaplastic fusiform cells that were negative for thyroglobulin (Tg) and were intermingled with cell groups positive for Tg (Fig. 2). The patient was treated with 5040 cGy radiotherapy to the cervical region and, 6 months later, with 280 mCi of 131iodine (I). The posttreatment whole-body scan (WBS) showed only thyroid bed uptake. One year later, cervical and brain magnetic resonance imaging, chest tomography, and abdominal US were negative, and serum Tg and anti-Tg antibodies were negative and undetectable. A WBS with thyroid hormone withdrawal performed 18 months after thyroidectomy was negative, but 1 month later the patient developed dyspnea, hip pain, and a left submandibular node. Chest tomography was consistent with pulmonary and left femur metastases. Fine-needle aspiration of the submandibular node and bronchial lavage cytology were suggestive of metastasis of anaplastic carcinoma. The patient died 2 months later. The patient reported here is quite unusual not so much for some of her many associations, namely, GD with epithelial cell TC and PTC with ATC, but for the simultaneous combination of three types of TC and GD. The coexistence of thyroid nodules and GD is widely described (2) and a number of studies have shown increased aggressiveness of TC in GD patients (3). Many investigators have strongly suggested that the thyroid-stimulating antibodies play a role in greater aggressiveness of thyroid FIG. 1. Histologic section of the right lobe of the thyroid showing the transition from follicular carcinoma and anaplastic carcinoma. H&E, 200.