Abstract
BackgroundIsotretinoin (ISO) is a synthetic vitamin A derivative which has been used for treatment-resistant acne vulgaris. Although most musculoskeletal side effects of ISO are common, including myalgia, arthralgia, and back pain, sacroiliitis is one of the uncommon side effects. ISO-induced sacroiliitis usually completely resolves within a few months by the cessation of the drug.Case presentationIn this paper, we present a 26-year-old female patient with chronic sacroiliitis that was probably induced by ISO and not resolved by the discontinuation of the drug.ConclusionIn this patient, sacroiliitis was overlooked for three years. Therefore, ISO usage should be considered in the differential diagnosis of sacroiliitis and low back pain.
Highlights
Isotretinoin (ISO) is a synthetic vitamin A derivative which has been used for treatment-resistant acne vulgaris
Isotretinoin (ISO) is a synthetic vitamin A derivative that has been used for treatment-resistant acne vulgaris patients for about 40 years
We present a case with chronic sacroiliitis which was triggered probably by ISO treatment and overlooked for 3 years
Summary
Isotretinoin (ISO) is a synthetic vitamin A derivative which has been used for treatment-resistant acne vulgaris. Isotretinoin (ISO) is a synthetic vitamin A derivative that has been used for treatment-resistant acne vulgaris patients for about 40 years. It was reported that the human leucocyte antigen B27 (HLA-B 27) positivity might predispose patients using ISO to the development of sacroiliitis [2]. The patient mentioned that she started to experience pain at the fourth months of ISO use, and she had no previous history of low back or buttock pain before this treatment.
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