Abstract
Sir, The start of publications of the Collegium Naturae Curiosum (the present German Academy of Natural sciences Leopoldino) in 1670 marks the world’s first medical and natural science journal. The journal appeared under several names and with some minor gaps in appearance. Between 1727 and 1754 it was published under the baroque-complicated title Acta Physico-Medica Academiae Caesareae Leopoldino-Carolinae Naturae Curiosum exhibentia Ephemerides sive Observationes Historias et experimenta a Celeberrimis Germaniae et exterarum regionum viris habita & communicata (Figure 1). Each volume contains hundreds of ‘observations’. The majority concerns medicine, others natural history and some other sciences. A contribution to the second volume that appeared in 1730, is a detailed observation of a patient suffering from a large intraand extracranial tumor, described by Johann Salzmann.
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