Abstract
Introduction : A study was undertaken to investigate the potential toxic effects of cypermethrin in adult Sprague Dawley male rats, with particular emphasis on its effect on the nervous and digestive systems. Materials and Methods: The clinical signs, gross and histological alterations were analyzed, to study the effects of different doses of cypermethrin. Results: Medium and high doses produced nervous signs in animals. Gross lesions were observed in the intoxicated groups, such as, bloat, congestion of lungs, heart, brain, pulmonary haemorrhage, and degenerative changes in the liver and kidneys. Microscopically effects on all organs were mild-to moderate degenerative changes at the low-dose level. Medium- and high-dose intoxicated groups revealed necrotic changes, extensive haemorrhages, congestion in organs like liver, kidney, and lungs apart from the changes observed in low-dose group animals. Conclusions: The text to abstract): The present study reveals that cypermenthrin can produce toxic effects in mammals at sublethal doses.
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