Abstract

The effect of ethacyzine (a diethylamine analogue of ethmozine) on the rapid inward sodium current (I Na) was studied in single rat ventricular muscle cells by a patch clamp technique. Extracellular application of 3 μM ethacyzine depressed the I Na in a use-dependent fashion. Rest recovery from the use-dependent block by ethacyzine followed an exponential time course with a time constant of about 215 ± 40 s (n = 4, mean ± S.E.).

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