Abstract
We used to understand Parkinson’s disease as a condition characterised by motor symptoms: tremor, rigidity, and bradykinesia. Recently we have started to think of it as a multisystem disorder with significant “non-motor symptoms” including depression, dementia, and constipation, which have considerable impact on quality of life. The clinical phenomenology of the condition is fascinating. The late Sir David Marsden, with his infectious interest and attention to clinical detail, was inspirational. The sense of satisfaction you get when you are able to control debilitating symptoms and help patients lead a more normal life. The time spent with patients, listening to them and observing their different problems, can be very rewarding. A little closer perhaps—cure implies both arresting the process and repairing …
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