Abstract
Based on a set of reaction-diffusion equations of oxygen, glucose and growth inhibitory factor which were built to describe the tumor growth environment, a cell cycle control factor was proposed for the simulation of the avascular tumor growth. In order to fix the model parameters, a two-level heuristic searching was given for the parameter selection. Finally, a total finite element energy equation was present to combine the chemical simulation and the physical simulation for the avascular tumor growth. Experimental results showed that the presented approach outperformed the baseline approach in the simulation of the mouse mammary tumor cells EMT6/Ro.
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