Abstract
Polymer microbead production by parallel plate electrostatic extrusion is presented. Factors affecting microbead size such as needle gauge, electrostatic potential, distance between needle and collecting solution, and polymer solution concentration and flow rate were evaluated. Smaller microbeads resulted from reduced needle diameter, reduced needle to collecting solution distance, increased electrostatic potential, and reduced polymer solution concentration and flow rate. In terms of process scale-up, it was shown that a multi-needle (20) device could continuously produce relatively uniform beads via electrostatics. The technology was demonstrated to be feasible for cell encapsulation or immobilization as there was no detectable effect of applied potential onSpodoptera frugiperda viability.
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