Abstract
A flexible, parchment paper/PDMS based platform for local wound oxygenation is fabricated and characterized. The platform consists of a PDMS microfluidic network bonded to a parchment paper substrate. Generation of oxygen occurs by flowing H2O2 through the channels and chemically decomposing it via a catalyst embedded in laser-defined regions of the parchment paper. PDMS is bonded to parchment paper using partially cured PDMS followed by a brief air plasma treatment, resulting in a strong bond. For pressures below 110Torr the parchment paper is observed to be impermeable to water and hydrogen peroxide. The oxygen permeability of parchment paper is measured to be 1.42μL/(Torrmm2min). Using a peroxide flow rate of 250μL/min, oxygen generation in the catalyst spots raises the oxygen level on the opposite side of the parchment paper from atmospheric levels (21%) to 25.6%, with a long-term (30h) generation rate of 0.1μLO2/min/mm2. This rate is comparable to clinically proven levels for adequate healing. Device and material in vitro biocompatibility is confirmed with NIH 3T3 fibroblast cells via alamar blue assays.
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