Abstract
Human coronavirus (HCoVs) pathogens are the cause of multiple respiratory epidemics since last 18 years, now has one more outbreak with novel evolution recognized in Wuhan, China in early December 2019. The novel corona virus 2019 is the most dangerous evolution of species SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) spread on 2003 and 2012 respectively, named “coronavirus disease 2019” (COVID-19) by the World health organization. The HCoVs have remarkably huge RNA genome, and an inimitable replication tactic. The current evolution COVID-19 has very high morbidity and mortality rate and has created world’s biggest health emergency ever. The outbreak is now declared pandemic by WHO. In this review we highlight history of HCoVs, epidemiology, possible genetic evolution, pathogenesis, diagnosis and current prevention and treatment strategies for COVID-19.
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