Abstract
Intracellular recordings were made from rat striatal neurones in vitro. In the presence of intracellular caesium and extracellular tetraethylammonium chloride (TEA) (5 mM) and barium (3 mM), long-lasting plateau potentials developed followed by a prominent voltage independent hyperpolarization which lasted several seconds. A similar afterhyperpolarization was observed when calcium was replaced by barium. The afterhyperpolarization was reduced in a potassium free medium and reversibly abolished in a Na +-free solution or by cooling the slice to 21–24°C. It was also irreversibly blocked by ouabain (50 μM). This hyperpolarization may therefore result from the activation of a Na +,K +-ATPase electrogenic pump.
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