Abstract
The conventional synthetic methods for the synthesis of primary amines require multiple steps and harsh nitrogen deprotection conditions, which lead to low overall yield. The authors described a one-pot synthesis of chiral primary amines through an asymmetric reductive amination-hydrogenolysis sequence. In spite of their low reactivity, they achieved the synthesis of ortho-substituted phenylethyl amines in good yield and with high enantioselectivity.
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