Abstract
The catalyst-free multicomponent reaction of 1,2-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. Ethylenediamine also reacts under similar conditions to produce new pyrrolo[1,2-a]pyrazine derivatives.
Highlights
Among the various classes of heterocyclic compounds, quinoxalines, a class of N-containing heterocycles, form an important component of many pharmacologically active compounds [1,2,3,4]
Quinoxaline derivatives are associated with a wide spectrum of biological effects including anticancer [8], antifungal, and antidepressant activities [9,10]
The syntheses of pyrrolo[1,2-a]quinoxaline derivatives have hitherto been reported by only a few researchers, and they normally required additional additives and long reaction times and displayed limited reaction tolerance and low reaction selectivity [20,21]
Summary
Among the various classes of heterocyclic compounds, quinoxalines, a class of N-containing heterocycles, form an important component of many pharmacologically active compounds [1,2,3,4].
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