Abstract
A four-step, one-pot synthesis of mixed α-azido-phosphonates and phosphonothioates 12a–d is described. This chemistry has provided a facile route to haptens 6a–b and 7 that have been employed for the elicitation of antibody ligases. Five hapten-specific antibodies have been identified as modest catalysts of a model peptide ligation reaction between thioester 1b and thiol 2 to give the amide product 5.
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