A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation

Abstract

A series of substituted dihydropyrimidin-2(1H)-thione derivatives (1–8) have been synthesized and docked against enzymes human topoisomerase II alpha (4FM9) and Helicobacter pylori urease (1E9Y) for binding mode validation.