Abstract
An efficient and simple protocol for the synthesis of a new class of diversely functionalized novel indole and coumarin containing pyridine-3-carbonitrile derivatives has been described through one-pot four-component condensation reaction of 3-(1H-indol-3-yl)-3-oxopropanenitrile, various aldehydes, 3-acetyl-2H-chromenones, and ammonium acetate in acetic acid conditions. The present new methodology offers several advantages such as short reaction time, easy experimental work-up, and good product yield, and endures the substrate diversity and operational simplicity under metal-free reaction conditions for the formation of C–C/C–N bonds.
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